Package: LoopDetectR 0.1.2

LoopDetectR: Comprehensive Feedback Loop Detection in ODE Models

Detect feedback loops (cycles, circuits) between species (nodes) in ordinary differential equation (ODE) models. Feedback loops are paths from a node to itself without visiting any other node twice, and they have important regulatory functions. Loops are reported with their order of participating nodes and their length, and whether the loop is a positive or a negative feedback loop. An upper limit of the number of feedback loops limits runtime (which scales with feedback loop count). Model parametrizations and values of the modelled variables are accounted for. Computation uses the characteristics of the Jacobian matrix as described e.g. in Thomas and Kaufman (2002) <doi:10.1016/s1631-0691(02)01452-x>. Input can be the Jacobian matrix of the ODE model or the ODE function definition; in the latter case, the Jacobian matrix is determined using 'numDeriv'. Graph-based algorithms from 'igraph' are employed for path detection.

Authors:Katharina Baum [aut, cre], Sandra Krüger [ctb]

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LoopDetectR.pdf |LoopDetectR.html
LoopDetectR/json (API)

# Install 'LoopDetectR' in R:
install.packages('LoopDetectR', repos = c('https://kathbaum.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • func_POSm4 - Example ODE function: chain model with positive regulation.
  • func_li08 - Example ODE function: bacterial cell cycle.
  • li08_solution - Solution for the cell cycle model related to func_li08

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

7 exports 0.00 score 12 dependencies 184 downloads

Last updated 4 years agofrom:6018976168. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKAug 25 2024
R-4.5-winOKAug 25 2024
R-4.5-linuxOKAug 25 2024
R-4.4-winOKAug 25 2024
R-4.4-macOKAug 25 2024
R-4.3-winOKAug 25 2024
R-4.3-macOKAug 25 2024

Exports:compare_loop_listfind_edgefind_loopsfind_loops_nosccfind_loops_vsetloop_summarysort_loop_index

Dependencies:clicpp11glueigraphlatticelifecyclemagrittrMatrixnumDerivpkgconfigrlangvctrs

LoopDetectR: Comprehensive Feedback Loop Detection in ODE models

Rendered fromworkflow_LoopDetectR.Rmdusingknitr::knitron Aug 25 2024.

Last update: 2020-07-20
Started: 2020-07-20